Baylor only led 22-18 with eight minutes left in the first half before closing on a 13-2 run for a 15-point lead at the break. Cincinnati made just one of its last 10 first-half field goals.
The closest Cincinnati got in the second half was 11 points, 39-28, after a 3-pointer by Dan Skillings Jr.
Josh Ojianwuna added 10 points and seven rebounds for Baylor (10-4, 2-1 Big 12).
Skillings finished with 18 points and five 3-pointers and Aziz Bandaogo scored 11 for Cincinnati (10-4, 0-3), which has lost three straight games. Simas Lukosius, a 6-8 senior guard from Lithuania averaging a team-best 13.6 points, was held to five points on 2-of-7 shooting.
The Bearkats were ranked 19th in the AP poll before single-digit losses to Kansas State (70-67) and Arizona (72-67) by a combined eight points.
Cincinnati returns home to host No. 11 Kansas on Saturday, when Baylor is at Arizona State.
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